Getting RIP’d Stunts Your Growth
نویسندگان
چکیده
The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.
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ورودعنوان ژورنال:
- Neuron
دوره 46 شماره
صفحات -
تاریخ انتشار 2005